This study observed that Cordyceps militaris supplementation improved VO2 max and exercise tolerance, likely due to its influence on ATP production and overall energy metabolism, which enhances endurance and performance in high-intensity exercise (Hirsch et al., 2017).
Cordycepin from Cordyceps militaris was found to significantly inhibit NO production and directly suppress the kinase activity of AKT by interacting with its ATP binding site. This suggests cordycepin's role in modulating ATP-dependent pathways to exert anti-inflammatory effects (Yoon et al., 2015).
After three weeks of supplementation with a mushroom blend containing Cordyceps militaris, there was a significant improvement in VO2 max and time to exhaustion during high-intensity exercise, suggesting enhanced exercise tolerance (Hirsch et al., 2017).
In a study involving healthy elderly volunteers, supplementation with Cordyceps sinensis (Cs-4) for six weeks significantly increased VO2 max and anaerobic threshold, indicating improved aerobic capacity and respiratory function (Yi et al., 2004).